Super agers : an evidence-based approach to longevity

Super agers An evidence-based approach to longevity

Eric J. Topol, 1954-

Book - 2025

"One of the most respected, celebrated, and influential medical researchers in the world gives a guided tour of the revolution in longevity science that is exploding now. This is an evidence-based approach to longevity in a market drenched in snake oil-Eric Topol doesn't promise a silver bullet to magically stop the aging process, he shows how preventing the development of killer chronic diseases like obesity, heart disease, cancer and neurodegeneration is completely changing what "old age" can be. And we can start long before middle age-or long after. Dr. Topol shows how and why you can deal with chronic problems now instead of waiting until it is too late. Breakthrough treatments have been developed from new tools, new... understanding of how our personal genomes work, and what AI can see in our health data. We can now engineer cells, build proteins and find drugs that make us live longer, better. Many of these treatments are on the shelf now-or soon will be-and improving fast. Our author is the ultimate guide because he participated in developing and testing many of them. The first part of the book "The New Age of Healthspan" describes inspiring patients aged 90+, sets out the dimensions of the new advances in the treatments of age related diseases, and details an expanded definition of what a healthy lifestyle means now-good sleep, diet, exercise, sure, but much beyond. He calls it Lifestyle+. He then turns to the "Chronic Killers"-Obesity/Diabetes, Heart Disease, Cancer, and Neurodegeneration. Parts on the "Big Collateral Implications" and "Thinking Ahead" follow and include ways we might eventually come to reverse the aging process itself"--

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Subjects
Longevity.
Aging > Physiological aspects.
Older people > Health and hygiene.
Medicine, Preventive.
Artificial intelligence > Industrial applications.
Vieillissement > Aspect physiologique.
Personnes âgées > Santé et hygiène.
Médecine préventive.
Intelligence artificielle > Applications industrielles.
Published
New York : Simon & Schuster [2025]
Language
English
Main Author
Eric J. Topol, 1954- (author)
Physical Description
452 pages : illustrations ; 25 cm
Bibliography
Includes bibliographical references and index.
ISBN
9781668067666
9781668067673
  • The age of healthspan. A tale of two patients ; It's in your genes? ; Lifestyle+
  • Chronic killers. Obesity and diabetes ; Cardiovascular disease ; Cancer ; Neurodegeneration
  • Great implications. Curing rare diseases ; Controlling our immune system ; Defeating infectious agents ; Maintaining mental health
  • Thinking ahead. Changing aging ; The path forward.
Review by Publisher's Weekly Review

Topol (Deep Medicine), a molecular medicine professor at Scripps Research, presents an exhaustive and occasionally exhausting resource for understanding the factors that shape how people age. Delving into how certain lifestyle choices tax one's health over time, he cites research showing that eating ultra-processed foods increases risk of heart disease, that regular exercise decreases the likelihood of developing cancer, and that getting less than six hours of sleep per night raises one's chances of getting dementia by 30%. He explains the science behind dangerous chronic conditions, describing, for instance, how uncontrolled high blood pressure leads to the buildup of plaque inside arteries that can eventually result in a heart attack. "Stopping our bodies from attacking themselves" is crucial to achieving longevity, Topol argues, discussing how one University of Calgary researcher recently found a way to deactivate inflammatory antigens with iron oxide nanoparticles. Elsewhere, Topol examines how a decline in cells' ability to clear faulty proteins contributes to neurodegeneration, and how music has shown promise treating Parkinson's disease in elderly patients. The expansive collation of studies features the most up-to-date science on aging, but the dry presentation and technical language are a drag ("A discovery in inflammatory bowel disease of intraepithelial lymphocytes with specific T cell receptor antigens tied to loss of self-recognition is one path to developing immune tolerance"). It's a mixed bag. Agent: Katinka Matson, Brockman, Inc. (May)

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