The first shots The epic rivalries and heroic science behind the race to the Coronavirus vaccine

Brendan Jonathan Borrell

Book - 2021

An award-winning journalist, drawing on high-level access, presents the full inside story of the high-stakes, global race of the lifesaving vaccine to end the pandemic.

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Subjects
Published
Boston : Mariner Books, an imprint of HarperCollinsPublishers [2021]
Language
English
Main Author
Brendan Jonathan Borrell (author)
Physical Description
xviii, 302 pages ; 24 cm
Bibliography
Includes bibliographical references (pages 275-286) and index.
ISBN
9780358569848
  • Cast of Characters
  • Prologue
  • Part 1. Emergence January 2020-March 2020
  • 1. Sounds Like It Could Be Fun
  • 2. Courage and Doubt
  • 3. Not Sanctioned, Not Authorized
  • 4. Our Bugs and Gas Guy
  • 5. Stabilizing the Spike
  • 6. Old School, New School
  • 7. Oceanic Outbreak
  • 8. Very Much Under Control
  • 9. The President's Powwow
  • 10. This Ain't Over
  • Part 2. Lockdown March 2020-May 2020
  • 11. A Company Is Born
  • 12. Running on Empty
  • 13. Masks for Everyone
  • 14. The Moonshot
  • 15. Return to Power
  • Part 3. Testing May 2020-October 2020
  • 16. Horse Race
  • 17. Battle Rhythm
  • 18. Masters of the Protocol
  • 19. Three Hundred Million Doses
  • 20. Plasma Drive
  • 21. Trials
  • 22. Tribulations
  • Part 4. Rollout October 2020-January 2021
  • 23. How Do You Know?
  • 24. Winter Wave
  • 25. Seniors First
  • 26. The N-Hour
  • 27. The Brave Endure
  • Afterword
  • Acknowledgments
  • Notes
  • Index
Review by Publisher's Weekly Review

Journalist Borrell debuts with a powerful behind-the-scenes look at Operation Warp Speed, the effort to develop a Covid-19 vaccine in record time. Through interviews with "current and former government officials and members of the Trump White House," Borrell focuses on the scientists who made use of cutting-edge genetic technologies to win the race to immunity. There's Moncef Slaoui, the operation's chief scientific adviser, who took the helm when "it was less than operational and it wasn't moving at warp speed," and Barney Graham, the deputy director at the National Institutes of Health's Vaccine Research Center, who was "out to prove that vaccine design could move faster than ever under his pathogen-preparedness model." Borrell also details the rivalries that slowed things down--Robert Kadlec, the assistant secretary in Health and Human Service's Office for Preparedness and Response, contacted an executive at Hanes in March 2020 and arranged with the company to produce cloth masks for every American household, only to have that nixed by Jared Kushner. Borrell's granular account reveals the inspiring work of scientists, who despite the holdups, succeeded "in spite of the politics at the time," and were "a testament to the grit and ingenuity of the American people." The result is a page-turning introduction to a key part of the pandemic. (Oct.)

(c) Copyright PWxyz, LLC. All rights reserved
Review by Library Journal Review

An Outside magazine correspondent whose award-winning journalism has appeared in venues ranging from the Atlantic to Wired, Borrell draws on exclusive emails and insider emails to track the race to produce The First Shots to protect against COVID-19; look for an HBO limited series. In Deep Denial, multi-award-winning CNN anchor Cuomo reflects on the fault lines in American society revealed by the pandemic--from a hobbled public health care system to a failure to commit to equality and racial justice--and more personal thoughts on home and family after he contracted COVID-19 and kept reporting from his basement (150,000-copy first printing). CNN chief medical correspondent, who's also been in the thick of COVID-19 reporting, Gupta gives us World War C, answering major questions on how the pandemic unfolded and what happens next, e.g., can we obliterate the virus and, if not, how do we live with it? (250,000-copy first printing). The pandemic has shown us the crucial work done in our communities by E.R. Nurses, and the mega-best-selling Patterson joins forces with Walk in My Combat Boots coauthor Matt Eversmann and Edgar finalist Chris Mooney to reveal the extent of our indebtedness.

(c) Copyright Library Journals LLC, a wholly owned subsidiary of Media Source, Inc. No redistribution permitted.
Review by Kirkus Book Review

How the Covid-19 vaccines came to be. Governments often dithered, but scientists and entrepreneurs were on the ball. Outside magazine correspondent Borrell delivers a vivid portrait of the combination of drudgery, greed, legerdemain, and brilliance that made the vaccines a reality in record time. The arrival of the pandemic in the U.S. in January 2020 galvanized America's public health establishment and a dozen pharmaceutical companies ranging from aggressive startups such as Moderna to international behemoths like Pfizer. All were aware that developing a vaccine is horrendously expensive and risky but that governments were eager to make every effort to ensure success. Still, the path remained bumpy. The old method of growing viruses in large stainless-steel vats was facing a new technology in which a vaccine consisted of bits of viral RNA that activate the body's immune response equally well. New or old, it had to work, and Borrell offers a meticulous, thrilling account of the testing process. First, researchers tested lab animals to determine if the vaccine protected them from the virus. It did. Then human volunteers received it to find a proper dose and check for side effects. Only then were thousands given either vaccine or placebo and then watched for months. Some vaccines flopped, but the best provided more than 90% protection. Led by Lawrence Wright's The Plague Year, most Covid books emphasize chaotic, self-serving politics and the pandemic's devastation, a dismal one-two punch. Borrell does not ignore ignorant or apathetic leaders, but by concentrating on the vaccines, he tells a story with a happy ending--at least as of May 2021, when his account ends. Drawing on extensive interviews, the author uncovers heroes and villains, works hard, if not always successfully, to explain virology and vaccine technology for a lay readership, and excels in recounting the cutthroat pharmaceutical world in which the process of developing a vaccine can bring riches or bankruptcy. An exciting, readable exploration of an extraordinary scientific breakthrough. Copyright (c) Kirkus Reviews, used with permission.

Copyright (c) Kirkus Reviews, used with permission.